Stereoselective Syntheses of 3′-Hydroxyamino- and 3′-Methoxyamino-2′,3′-Dideoxynucleosides
نویسندگان
چکیده
منابع مشابه
Broad spectrum antiretroviral activity of 2',3'-dideoxynucleosides.
Certain dideoxynucleosides have been shown to markedly inhibit the infectivity of human T-lymphotropic virus type III/lymphadenopathy-associated virus, the causative agent of acquired immunodeficiency syndrome (AIDS). Our present studies demonstrate that these drugs are broad spectrum antiretroviral agents capable of inhibiting the infectivity of evolutionarily divergent mammalian type C and an...
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It is generally accepted that human immunodeficiency virus (HIV) is the etiologic agent of the acquired immunodeficiency syndrome and related diseases. In this report, we demonstrate the antiviral effect of nucleoside analogs 2',3'-didehydro-2',3'-dideoxythymidine (DHT) and 2',3'-didehydro-2',3'-dideoxycytidine (DHC) by using human T-cell lymphotropic virus type I-carrying MT-4 cells, which are...
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متن کاملCorrection: Vol. 23, No. 3
T use of antimicrobial drugs in food-producing animals can result in antimicrobial drug–resistant infections in humans. A good example is the use of fluoroquinolone in poultry and the emergence of fluoroquinolone-resistant Campylobacter infections among humans. However, topics of intense debate include the widespread use of antimicrobial drugs in animals, the extent to which antimicrobial drug ...
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2019
ISSN: 1523-7060,1523-7052
DOI: 10.1021/acs.orglett.9b03474